Soft Tissue Grafting with AlloDerm Regenerative Tissue matrix

Root Coverage results comparable to autologous tissue

AlloDerm consists of a collagen matrix that preserves all the elements necessary for revascularization and cellular repopulation. Multiple prospective human clinical investigations have documented equivalent root coverage results to connective tissue grafts.2-9

Multiple investigations have also documented esthetic results equivalent to autologous connective tissue.2,5,7,9  AlloDerm serves as a scaffold for epithelial cell migration, thus allowing pigmentation and contour to emulate surrounding tissues.

With AlloDerm you can treat multiple sites in a single surgery. You are not limited by the amount of tissue you can harvest from the palate. AlloDerm gives you an option for treating patients that have inadequate harvestable tissue (due to age or compromised health) or simply prefer not to have a palatal harvest.

Pre-operative	Post-operative

Soft tissue ridge augmentation

AlloDerm can be used in a variety of oral grafting procedures such as soft tissue ridge augmentation. A tunnel or pouch may be created beneath the defect into which the AlloDerm can be inserted. If multiple layers of AlloDerm will be used for increased volume, it is recommended that it be layered, rather than rolled. In this indication, it is preferable to orient the connective tissue surfaces on the outside of the graft (sandwiching the basement membrane sides in the middle).

Pre-operative	Post-operative

Increasing vestibule depth

AlloDerm is especially useful in mandibular overdenture cases where a free gingival graft procedure is needed to widen the area of attached gingiva and increase the depth of the vestibule. Keys to success with this procedure include scoring the periosteum to promote revascularization of the graft, treatment planning to account for approximately 40% shrinkage, and secure fixation of the graft with either sutures or tacks.

Pre-operative	Post-operative

AlloDerm Regenerative Tissue Matrix

AlloDerm is widely used in both medicine and dentistry for plastic and reconstructive surgery. Originally developed to treat burn patients, it is now used in general surgery, orthopedic surgery and urogenital surgery in addition to its applications in dental surgical procedures. Since its introduction in 1994, there have been more than 900,000 AlloDerm grafts placed with no incidence of disease transmission.1

AlloDerm is a processed tissue that comes from donors who are extensively screened and tested for presence of diseases including HIV and hepatitis. The processing procedure has been demonstrated to reduce HIV and hepatitis C surrogate virus to non-detectable levels. Additional testing for presence of pathogens is performed prior to and following processing to ensure that AlloDerm is disease-free before release for patient care.

AlloDerm Processing

A buffered salt solution removes the epidermis, and multiple cell types within the dermis are then solubilized and washed away using a patented series of non-denaturing detergent washes that rapidly diffuse into the dermis.

The processed regenerative human tissue matrix is then preserved using a patented freeze-drying process, which prevents damaging crystal formations, thereby retaining the critical biochemical and structural components needed to maintain the tissue's natural regenerative properties.

1. Data on File.
2. Harris R, A Comparative Study of Root Coverage Obtained with an Acellular Dermal Matrix Versus a Connective Tissue Graft. IJPRD Periodontol, 20:51-59, 2000.
3. Mahn D, Treatment of Gingival Recession with a Modified Tunnel Technique and an Acellular Dermal Connective Tissue Allograft. PPAD, 13:201-208, 2001.
4. Shulman J, Clinical Evaluation of an Acellular Dermal Allograft for Increasing the Zone of Attached Gingiva. PPAD, 8: 201-208, 1996.
5. Dodge et al., Root Coverage without a Palatal Donor Site, Using an Acellular Dermal Matrix. Periodontol Insights, 5-9, 1998.
6. Henderson R et al., Predictable Multiple Site Root Coverage Using an Acellular Dermal Matrix Allograft. J. Periodontol, 72:571-582, 2001.
7. Tal H, Subgingival Acellular Dermal Matrix Allograft for the Treatment of Gingival Recession. J. Periodontol, 70:1118-1124, 1999.
8. Batista et al., Management of Soft Tissue Ridge Deformities with Acellular Dermal Matrix: Clinical Approach and Outcome After Six Months of Treatment. J. Periodontol, 72:1118-1124, 2001.
9. Wei et al., Acellular Dermal Matrix Allografts to Achieve Increased Attached Gingiva. Part 1. A Clinical Study. J. Periodontol, 71:1297-1305, 2000.
10. Froum S, Cho S, Elian N, Rosenberg E, Rohrer M, and Tarnow D, Extraction Sockets and Implantation of Hydroxyapatites With Membrane Barriers, A Histologic Study. Implant Dentistry 13(2):153-164, 2004.

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