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Prolifica

Allogenic growth factors

Prolifica is a naturally occurring blend of allogenic growth factors, stabilized by native human collagen and delivered in their intrinsic structure,
concentration and composition.

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16 unique proteins

Processed to preserve the natural biphasic release of proteins, this advanced allograft supports bone healing and regeneration across a range of clinical applications. Prolifica retains a minimum of 16 unique proteins that are known to support different aspects of cell growth, division and the complex biological processes involved in bone healing and tissue regeneration.1, 2, 3, 4

Sustained release

Prolifica delivers an initial surge of proteins and growth factors to support the initiation of the healing cascade, followed by a prolonged, sustained release for continued regenerative support.1

Applications4

  • Standalone bone grafting procedures
  • Bone grafting procedures in combination with autologous bone or other forms of allograft bone

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Additional information

Biomaterials product catalog
Detail sheet
Preparation guide

1. Data on file at the legal manufacturer, Xtant Medical, MRK-000049 (B) 8/25
2. Toosi S, Behravan J. Osteogenesis and bone remodeling: A focus on growth factors and bioactive peptides. Biofactors. 2020 May;46(3):326-340. doi: 10.1002/biof.1598. Epub 2019 Dec 19. PMID: 31854489.
3. Xu J, Yu L, Liu F, Wan L, Deng Z. The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review. Front Immunol. 2023 Jul 5;14:1222129. doi: 10.3389/ fimmu.2023.1222129. PMID: 37475866; PMCID: PMC10355373.
4. Reference manufacturer’s Instructions for Use (IFU) package insert.
Reorder Items
Additional information
6 items
How to Reorder
  • • Drag items by their ⋮⋮ handle to reorder
  • • Move items between different accordion sections
  • • Drop into empty areas to create new groupings
  • ⋮⋮
    Documents
    • ⋮⋮
      Biomaterials product catalog
    • ⋮⋮
      Detail sheet
    • ⋮⋮
      Preparation guide
  • ⋮⋮
    References
    • ⋮⋮
      1. Data on file at the legal manufacturer, Xtant Medical, MRK-000049 (B) 8/25
      2. Toosi S, Behravan J. Osteogenesis and bone remodeling: A focus on growth factors and bioactive peptides. Biofactors. 2020 May;46(3):326-340. doi: 10.1002/biof.1598. Epub 2019 Dec 19. PMID: 31854489.
      3. Xu J, Yu L, Liu F, Wan L, Deng Z. The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review. Front Immunol. 2023 Jul 5;14:1222129. doi: 10.3389/ fimmu.2023.1222129. PMID: 37475866; PMCID: PMC10355373.
      4. Reference manufacturer’s Instructions for Use (IFU) package insert.
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