ABSTRACT
In a root-form dental implant, functional thread surface area is defined as the area that is able to dissipate compressive and tensile (nonshear) loads to the bone and provide initial stability upon implant placement. Functional surface area establishes the portion of the implant surface that provides for initial osteoblast contact to the implant surface. Together, functional surface area and the host bone density determine the biomechanical load distribution of the implant. This investigation, based on mathematical models and validated by computer models, determined the functional surface area for three thread forms found in dental implant designs: the v-thread, the reverse buttress, and the square thread. The results of this investigation demonstrate that substantially greater functional surface area can be obtained in a square thread from, and that the surface area increases by varying geometric thread-form parameters, such as pitch and thread depth.

© Compend Contin Educ Dent. 1998;19(spec issue):4-9.

ABSTRACT
Component fracture and screw loosening are prevalent concerns of contemporary dental implants. This laboratory investigation examined the influence of design factors such as the platform diameter and the hex height on the mechanical strength and quality of fit of the implant abutment interface. Static and compressive bending tests were conducted on 4 and 5 mm diameter bone density-based implants. SEM evaluation of the implant-abutment interface was also conducted to assess the quality of fit between mating components. The 5 mm diameter implant was stronger in both static and fatigue conditions than the 4 mm diameter implants. A comparison of the results in published literature indicated that both implants were equal to or superior to alternative prosthetic connections in an identical testing configuration. Test results demonstrated the validity of wide diameter implants to reduce the likelihood of component fracture in contemporary dental implant systems.

© J Prosthet Dent. 1999 Oct;82(4):436-440.

ABSTRACT

Objectives:
While caution in the use of small-diameter (≤3.5 mm) implants has been advocated in view of an increased risk of fatigue fracture under clinical loading conditions, a variety of implant designs with diameters <3 mm are currently offered in the market for reconstructions including fixed restorations. There is an absence of reported laboratory studies and randomized-controlled clinical trials to demonstrate clinical efficacy for implant designs with small diameters. This laboratory study aimed to provide comparative data on the mechanical performance of a number of narrow commercially marketed implants.

Materials and Methods:
Implants of varying designs were investigated under a standardized test set-up similar to that recommended for standardized ISO laboratory testing. Implant assemblies were mounted in acrylic blocks supporting laboratory cast crowns and subjected to 30° off-axis loading on an LRX Tensometer. Continuous output data were collected using Nexygen software.

Results:
Load/displacement curves demonstrated good grouping of samples for each design with elastic deformation up to a point of failure approximating the maximum load value for each sample. The maximum loads for Straumann (control) implants were 989 N (±107 N) for the 4.1 mm RN design, and 619 N (±50 N) for the 3.3 mm RN implant (an implant known to have a risk of fracture in clinical use). Values for mini implants were recorded as 261 N (±31 N) for the HiTec 2.4 mm implant, 237 N (±37 N) for the Osteocare 2.8 mm mini and 147 N (±25 N) for the Osteocare mini design. Other implant designs were also tested. Conclusions:
The diameters of the commercially available implants tested demonstrated a major impact on their ability to withstand load, with those below 3 mm diameter yielding results significantly below a value representing a risk of fracture in clinical practice. The results therefore advocate caution when considering the applicability of implants ≤3 mm diameter. Standardized fatigue testing is recommended for all commercially available implants.

Notable quotes:

• Fractures have been reported following the clinical use of well-documented implant designs. (Adell et al. 1981; Morgan et al. 1993; Rangert et al. 1995; Eckert et al. 2000)
• One recent systematic review reported that implant fractures constitute between 5% and 20% of all implants lost during function. (Ber glundh et al. 2002)
• Various workers have previously highlighted the risk of fatigue fracture of smaller diameter implants, especially in areas of high loading. (Rangert et al. 1995; Polizzi et al. 1999; Ronouard & Rangert 1999; Eckert et al. 2000; Zinsli et al. 2004)

© Clin. Oral Impl. Res. 2008 May;19(6):553-559.

Purpose:
The different implant systems available today present several types of surface treatments, with the aim of optimizing bone-implant contact. This study compared 4 different types of implant surfaces.

Materials and Methods:
The first, second, third, and fourth mandibular premolars were extracted from five young, adult mongrel male dogs. Ninety days after removal, four 3.75-mm-diameter, 10-mm-long screw-type implants (Paragon) were placed with different surface treatments in mandibular hemiarches. The dogs received two implants of each of the following surface treatments: smooth (machined), titanium plasma spray (TPS), hydroxylapitite coating (HA) and sandblasting with soluble particles (SBM).

The implants were maintained unloaded for ninety days. After this period, the animals were sacrificed, and the hemimandibles were extracted and histologically processed to obtain non-decalcified sections. Two longitudinal ground sections were made for each implant and analyzed under light microscopy, coupled to a computerized system for histomorphometry.

Results:
The following means were obtained for bone-implant contact percentage: machined = 41.7%, TPS = 48.9%, HA = 57.9%, and SBM = 68.5%.

Discussion:
The means for all treatments that added roughness to the implant surface were numerically superior to the mean found for the machined surface. However, this difference was statistically significant only between groups SBM and machined (Tukey test, P < .05).

Conclusions:
The SBM-treated surface provided a greater bone-implant contact that a machined surface after 90 days without loading in this model.

© Int J Oral and Maxillofac Implants 2002;17:377-383 Note: SBM (Sandblasted with Soluble Particles Medium) is equivalent to RBT (Resorbable Blast Texturing) surface treatment. Both surface treatments are performed by Bio-Coat in Southfield, Michigan.

Background:
Dental implant thread geometry has been proposed as a potential factor affecting implant stability and the percentage of osseointegration. Therefore, the aim of this prospective, randomized, parallel arm study was to evaluate the effects of dental implant thread design on the quality and percent of osseointegration and resistance to reverse torque in the tibia of rabbits.

Methods:
Seventy-two custom-made, screw-shaped, commercially pure titanium implants (3.25 mm diameter x 7 mm length) were placed in the tibiae of 12 white New Zealand rabbits. Each tibia received three implants of varying thread shapes: one with a V-shaped, one with a reverse buttress, and one with a square thread design.

The rabbits were sacrificed following an uneventful healing period of 12 weeks. Implants in the right tibiae underwent histologic and histomorphometric assessments of the bone-to-implant contact (BIC) and the radiographic density of surrounding bone, while implants in the left tibiae were used for reverse-torque testing. Differences between the three thread designs were examined using analysis of variance (ANOVA).

Results:
Data showed that the square thread design implants had significantly more BIC and greater reverse-torque measurements compared to the V-shaped and reverse buttress thread designs, while no differences were found in radiographic bone density assessments.

Conclusion:
These results indicate that the square thread design may be more effective for use in endosseous dental implant systems.

© J Periodontol 2004;75:1233-1241

ABSTRACT
Background:
Immediate loading of dental implants has been introduced as a method of reducing implant treatment time without compromising its prognosis. In this research, the effects of loading time on the amount of bone-to-implant contact and bone formation around dental implants were evaluated histologically. Methods:
Three months prior to implantation, the lower premolar teeth of 15 dogs were extracted. Three or four dental implants were placed in the healed extraction sites for each dog (N = 48). Dividing the dogs into three groups, the implants were either loaded 48 hours or 1 week later with metallic or prefabricated acrylic crowns or were left unloaded until the time of sacrifice. Three months after implant insertion, the animals were sacrificed and samples were investigated to define the amount of bone-to-implant contact, lamellar and woven bone percentage, and local inflammation of the newly formed bone. Results:
No significant difference in the observed criteria was reported among the three groups (P >0.05); however, the unloaded group had the highest degree of bone-to-implant contact and the group loaded 48 hours after the primary implant insertion had the least. The prosthesis type had no significant effect on the implant success rate (P>0.05). The lamellar and woven bone percentage of newly formed bone also did not differ in the three groups (P>0.05). One implant from each group failed in this study. Conclusion:
Loading time does not seem to significantly affect the degree of osseointegration and bone-to-implant contact and the composition of newly formed bone around dental implants. © J Periodontol. 2006;77(10)1701-1707.

Mathematical and in-vitro models have demonstrated that a new, square thread, dental implant design increases functional surface area and improves loading profiles in contiguous bone. The aim of this investigation was to evaluate the histological response of bone to loading in a canine model. Implants were placed in the mandibles of beagle dogs after induced posterior, partial edentulism.

Three months after implantation, the animals received independent, fixed partial dentures, and were followed for an additional six months. Histological analysis revealed that each implant was osseointegrated with a mean bone contact length percentage of 53.7%.

An interesting observation was the formation of more bone on the inferior aspect of the square thread and concentric lamellar bridging adjacent threads. These observations suggest a beneficial effect of the square thread geometry on bone remodeling and more rapid formation of stronger lamellar bone.

© Implant Dent 2000;9:252-260

The aim of the present study was a comparison of bone's response to a machined surface and to a surface sandblasted with hydroxylapitite (HA) particles and resorbable blast material (RBT). Threaded machined and RBT, grade 3, commercially pure, titanium, screw-shaped implants were used in this study.

Twenty-four New Zealand white mature male rabbits were used. The implants were inserted into the articular femoral knee joint according to a previously described technique. Each rabbit received 2 implants, 1 test (RBT) and 1 control (machined). A total of 48 implants (24 control and 24 test) were inserted. The rabbits were anesthetized with intramuscular injections of fluanisone (0.7 mg/kg body weight) and diazepam (1.5mg/kg b.wt.), and local anesthesia was given using 1 ml of 2% lidocaine/adrenalin solution.

Two rabbits died in the postoperative course. Four animals were euthanatized with an overdose of intravenous pentobarbital after 1,2,3, and 4 weeks; 6 rabbits were euthanatized after 8 weeks. A total of 44 implants were retrieved. The specimens were processed with the Precise 1 Automated System to obtain thin ground sections. A total of 3 slides were obtained for each implant.

The slides were stained with acid and basic fuchsin and toluidine blue. The slides were observed in normal transmitted light under a Leitz Laborlux microscope, and histomorphometric analysis was performed. With the machined implants, it was possible to observe the presence of bone trabeculae near the implant surface at low magnification. At higher magnification many actively secreting alkaline phosphatase positive (ALP+) osteoblasts were observed. In many areas, a not yet mineralized matrix was present.

After 4 to 8 weeks, mature bone appeared in direct contact with the implant surface, but in many areas a not yet mineralized osteoid matrix was interposed between the mineralized bone and implant surface. In the RBT implants, many ALP+ osteoblasts were present and in direct contact with the implant surface. In other areas of the implant perimeter it was possible to observe the formation of an osteoid matrix directly on the implant surface. It must be stressed that these results have been obtained in a passive, nonloaded situation.

© J Oral Implantol 2002;28:2-8

ABSTRACT
This report presents the data from a prospective study of a bone quality based implant system. The surgical survival of 975 implants was 99.4%, with 100% survival in D4 bone. Three critical phases of bone loss were identified: bone remodeling from stage I to stage II surgery; stage II uncovery to prosthesis delivery (transition period); and prosthesis delivery up to the first year loading (early loading bone loss). The stage I to stage II uncovery crestal bone remodeling resulted in a mean vertical bone loss of .021 mm to 0.36 mm (SD = 0.90 mm), dependent on whether the implant became exposed to the oral cavity during osseous healing. No statistically significant difference was found among the four implant designs, implant diameter, bone density or location. The stage II uncovery to prosthesis delivery mean vertical bone loss ranged from 0.12 mm to 0.20 mm. One hundred three consecutive patients were restored, with 360 implants and 105 prosthesis in function for a period of 12 to 26 months. No early loading implant failure occurred. The mean early loading bone loss was 0.29 mm (SD = 0.99 mm). Past clinical reports indicate most failures or crestal bone loss occur by the first year of loading. This study suggests the bone quality based dental implant design minimizes overall failure and crestal bone loss, regardless of bone density.

© J Oral Implantol. 1999;25(3):185-197.

ABSTRACT
Background: The purpose of this case series study was to evaluate posterior single-tooth implant survival and the long-term conditions of the adjacent teeth.

Methods: A retrospective evaluation of 1,162 consecutive patients with a single missing posterior tooth treated with 1,377 external hex implants supporting 1,365 restorations surrounded by natural teeth over a 1- to 10-year period was reviewed from four private offices. Implant survival data were collected relative to stage I to stage II healing, stage II to prosthesis delivery, and prosthesis delivery to up to 10 years of follow-up. Long-term adjacent tooth conditions were assessed, including decay, endodontic therapy (root canal therapy [RCT]), and/ or extraction during the follow-up period.

Results: Of the 1,377 implants inserted, there were 11 surgical failures from stage I to stage II healing. There was one failure from stage II healing to prosthesis delivery. There were two prosthetic-phase failures. The surgical success rate was 99.2%, whereas the overall survival rate was 98.9% at an average of 61 months of follow-up (range, 12 to 125 months). A total of 2,589 adjacent teeth were followed during the study. No natural adjacent tooth was lost during this period. Interproximal decay developed in 129 adjacent teeth (5%), and nine adjacent teeth required RCT (0.4%) as a result of decay or restoration.

Conclusions: The use of single-tooth implants as replacements for posterior missing teeth is a viable long term treatment. Adjacent natural teeth complications are minimal for as long as 10 years after implant insertion.

© J Periodontol. 2008 Dec;79(12):2378-2382.

This article reports the five-year results of an independently monitored, prospective, multi-center, clinical trial of a bone quality-based implant design. At six study centers, 495 implants were placed in 151 cases with an average follow-up period of 1.6 years (range 1.0 to 3.6 years), following prosthesis delivery.

The majority of the implants placed were D2 or D3 implants to support fixed partial dentures or implant-supported overdentures. Using strict success criteria, there were three implant failures, resulting in a cumulative 99.5% success rate according to Kaplan-Meier survival analysis.

Radiographic analysis revealed a mean bone loss of 0.06 mm at one year and bone gain of 0.04 mm at two years following prosthesis loading. There were no statistical differences in the results by center, implant type, bone density, area of the mouth, or prosthesis type. The results of this five-year study revealed a high success rate and limited bone loss in all areas of the mouth, independent of bone quality.

© Implant Dent 2002;11:224-234

ABSTRACT
Purpose: The aim of this retrospective analysis was to report on the clinical outcome of immediate provisionalization using one-piece narrow diameter implants.

Materials and Methods: The dental records of patients who received narrow implants were reviewed. Narrow-diameter (3.0-mm) onepiece implants were used to support restorations of missing maxillary lateral incisors and mandibular incisors. All implants were placed in a one-stage procedure according to the protocol recommended by the manufacturer, with immediate placement o f provisional restorations. Following an average healing period of 3 months in the mandible and 5 months in the maxilla, the definitive prostheses were fabricated. The survival rate of the implants was analyzed, and radiographic evaluation was performed.

Results: Thirty-six patients (20 men and 16 women), aged from 42 to 72 years (average age of 53 years), were treated with 62 one-piece narrow implants. A success rate of 100% was observed over a period up to 33 months (mean, 23 ± 4.3 months). Among these, 8 implants were placed in maxillary lateral incisor positions and 54 implants were placed in mandibular incisor areas. Forty-four implants supported fixed partial prostheses, and 18 implants supported single crowns. The majority of the implants were 15 mm in length. Mean marginal bone loss at the 12-month follow-up visit was 0.53 ± 0.37 mm (range, 0 to 1.4 mm).

Conclusions:The results obtained in the retrospective analysis suggest that the one-piece narrow-diameter implant can predictably restore missing maxillary lateral incisors and mandibular incisor with narrow interdental spaces and labiolingual widths.

© Int J Oral Maxillofac Implants. 2011 Jan-Feb, 26(1): 163-8.

Purpose:
The objective of this study was to determine changes in interdental papillae, alveolar bone loss, esthetics, and initial healing success when one-piece narrow diameter implants are immediately loaded in limited tooth-to-tooth spacing sites.

Materials and Methods:
31 implants were placed in 17 subjects. Digital photographs were made at each clinical visit to assess soft tissue healing. Interproximal soft tissue fill of the embrasure was assessed with a modified Jemt index. Standardized radiographs were made at baseline (implant placement) and at interim healing (6 and 12 months post-surgery). Radiographic bone height was measured from a consistent landmark on the implant. A one-sided t-test was used to determine statistical differences of bone height.

Results:
One implant had clinical mobility and was removed for an overall survival rate of 96.7%. Mean bone height on the day of placement and restoration was 2.33 ± 0.73mm above the first thread. Mean bone height at 6 and 12 months post restoration was 1.75 ± 0.78; 1.63 ± 0.81mm respectively. There was a statistically significant loss of bone support over the initial six months (0.58mm; p<0.01) with no significant progression thereafter (0.12mm; NS). Complete fill of the papillae was found in 92% of maxillary lateral sites and 60% of mandibular incisor sites.

Discussion and Conclusion:
The use of narrow diameter one-piece immediately loaded implants appears to be an effective prosthetic treatment for areas of limited spacing.

© Int J Oral Maxillofac Implants. 2008 Mar-Apr;23(2):281-288

Background:
The immediate loading treatment concept can be successfully used in implant dentistry. Bone cells migrate onto the implant surface and establish a stable anchorage on the titanium surface. When implants are loaded immediately after surgery, there is a high long-term success rate of the implant-supported reconstruction.

Based on histologic observations from different animal studies, the interface of immediately loaded implants can have a direct bone-to-implant connection without any fibrous tissue formation. Mature bone formation is dependent on the loading period. The aim of this study was to demonstrate a histologic analysis of retrieved, clinically stable immediately loaded implants with different implant designs and surfaces. An objective demonstration of the bone-implant interface was presented for the implant systems used.

Methods:
A total of 29 implants [N. BioHorizons = 6] with different implant designs and surfaces were retrieved from patients who were treated with implants using an immediate loading protocol and fixed immediate restorations placed the same day after surgery. The loading period was between 2 and 10 months. The bone-implant interface was examined histologically and histomorphometrically.

Results:
A high bone-to-implant percentage of 66.8% (±8.9%) [BioHorizons BIC% = 80.6%] was found in the examined retrieved implants. Some marginal bone resorption was observed in the crestal part of the implants.

Conclusion:
According to the present histologic and histomorphometric evaluation of retrieved, clinically stable implants, immediate occlusal loading can present a high level of bone-to-implant contact in humans.

© J Periodontol 2005; 76:1823-1832

Background:
The aim of this study was the evaluation, from a clinical point of view, of implants subjected to immediate functional loading (IFL) and to immediate non-functional loading (INFL) in various anatomical configurations.

Methods:
The study included 152 patients who had given their informed consent. A total of 646 implants [N. BioHorizons = 242] were inserted. The implants were placed in 39 totally edentulous mandibles, 14 edentulous maxillae, 23 edentulous posterior mandibles, 16 edentulous anterior mandibles, 16 edentulous anterior maxillae, and 15 edentulous posterior maxillae. Fifty-eight implants were used to replace single missing teeth. In 65 cases, IFL was carried out for 422 implants. INFL was carried out in 116 cases, (224 implants).

Results:
In the IFL group 6 of 422 implants failed (1.4%) [N. BioHorizons = 0/0%] ; in the INFL group 2 of 224 implants failed (0.9%) [N. BioHorizons = 0/0%]. All the other implants appeared, from clinical and radiographic observations, to have successfully osseointegrated and have been functioning satisfactorily since insertion. All failures were observed in the first few months after implant loading.

Conclusion:
Immediate functional and non-functional loading seems to be a technique that gives satisfactory results in selected cases.

© J Periodontol 2003;74:225-241

Background:
The concept of immediate loading of root-form implants for fixed restorations has received increasing interest over the last 5 years. Several authors have commented on parameters that may influence results, including implant number; implant length, bone density, and patient habits. The trigger for bone remodeling around an implant may occur from the surgical trauma of insertion or the mechanical environment of strain at the interface.

In the classic two-stage approach, these were divided episodes, separated by 3 to 6 months. Immediate loading compresses this time frame; the two driving mechanisms for bone repair occur concurrently. A scientific approach to the interface development is to match the bone healing response of trauma (woven bone of repair) to the response of mechanical load (reactive woven bone), so the sum of these two entities does not result in fibrous tissue formation and clinical mobility of the implant.

Purpose:
It is the purpose of this article to review the scientific rationale of these statements and coordinate them to bone physiology and bone biomechanics. Materials and Methods: Findings from previous reports in the literature were reviewed and summarized to form the basis of a prospective study using a bone quality-based implant system (Maestro, BioHorizons Implant Systems, Inc., Birmingham, AL, USA).

A transitional prosthesis was delivered either on the day of surgery or within 2 weeks for 30 patients and 31 arches. A total of 244 implants were used to support these restorations, for an average of 7.8 implants per prosthesis. After 4 to 7 months, the final restorations were fabricated. One year after the final restoration was loaded, the implant survival was 100%; the 31 restorations also had a survival of 100% over this time frame. This report presents these implants and restorations over a 1- to 5-year period, with an average follow-up period of 2.6 years.

Results:
The bone loss from implant insertion to final prosthesis delivery averaged 0.7 mm. The first-year bone loss after final prosthesis delivery averaged 0.07 mm. A slight increase in bone height was observed after the first year, but generally no increase was observed over the remaining evaluation period.

Conclusions:
In the current report, no implant failure occurred, and crestal bone loss values were similar to or less than values reported with the conditional two-stage approach. This may be related to the number and position of implants, implant design, and/or the surface condition of the implant loading.

© Clin Implant Dent Relat Res 2003;5:17-28

ABSTRACT
Background: Clinical, radiographical, and histological findings have shown that immediately loaded implants show the presence of mineralized tissues at the interface.

Purpose: The aim of this study was to compare an immediate loading protocol with a two-staged one using an implant with a square thread design.

Materials and Methods: One hundred fifty-five consecutive patients (71 men, 84 women), aged between 18 and 78 years (mean: 54 years) participated in this study. A total of 550 implants (Maestro; BioHorizons, Birmingham, AL, USA) were inserted. In group A, 264 implants were inserted in 82 patients with immediate functional loading with occlusal contact if the patients were completely edentulous, or with immediate nonfunctional loading without occlusal contact if the patients were partially edentulous. In group B, 286 implants were inserted in 73 patients with a one-stage or two-stage surgical procedure. All patients were followed for at least 5 years.

Results:In the immediately loaded implants group, three implants failed, all in posterior mandibular sites, with an overall 98.8% 5-year survival rate. In the control group, no implant failed, with a 100% 5-year survival rate. No statistically significant differences were found in the survival rates of the implants in the two groups.

Discussion: A very high implant survival rate was also present in our series for the immediately loaded implants. All the three failed implants were retrieved from the same patient, who had poor oral hygiene, after a loading period of 5 years. These data can suggest that, from a clinical point of view, an abbreviated healing period is compatible with the development and maintenance over a longer time period (5 years) of mineralized tissues at the interface with dental implants.

Conclusion: We can then conclude that shorter healing periods can be highly satisfactory from a clinical point of view.

© Int J Oral Maxillofac Implants. 2011 Jan-Feb, 26(1): 163-8.

Immediate loading is a surgical-prosthetic procedure extensively used in implant dentistry. Despite its frequent use, minimal data are available on the long-term clinical success rate of immediate functional loading (IFL) and immediate nonfunctional loading (INFL) of implants. The aim of this study was to evaluate the long-term survival and bone loss of immediate nonfunctional single implant restorations in a group of patients that were monitored for 5 years.

One hundred and eleven patients (41.4% men) with a median age of 40 years were included in this study. A total of 111 implants were placed. All implants were placed with a minimum insertion torque of 25 Ncm. A temporary restoration was relined with acrylic resin, trimmed, polished, and cemented or screw retained 1 to 2 hours later. Occlusal contact was avoided in centric and lateral excursions.

After provisional crown delivery, a periapical radiograph was performed by means of a customized Rinn holder device. Data were analyzed by means of Kaplan-Meier and life-table algorithms. Stratification of implant survival was performed for the available variables of interest, and comparisons were analyzed using a log-rank test.

Investigated parameters were time of implant placement, bone quality, implant site, implant diameter and length, and type of implant surface enhancement. The parameters for overall success rate were defined by bone resorption <1.5 mm after the first year of loading and <0.2 mm thereafter. During the 5-year follow-up period, a survival rate of 95.5% was observed. All failures occurred within 4 months of implant loading.

There were statistically significant differences regarding healed vs. post-extraction implant sites (100% and 92.5%, respectively, P = .05) and type of bone (D1 vs. D4 yielded 100% and 95.5%, respectively, P <.05). No differences were detected for: (1) site (100% for mandible and 94.6% for maxilla, P =.319); (2) implant diameter (survival rates of 97.26% for <4.5-mm diameter and 92.11% for >4.5- mm diameter, P =.206); (3) implant lengths (survival rates of 96.97% for implants >13 mm and 94.87% for implants <13 mm, P=.624); and (4) type of implant surface enhancement (survival rates of 94.03% for 67 cases of grit-blasted and acid-etched surfaces and a failure rate of 4 out of 5, and 94.12% for 17 cases of hydroxyapatite (HA)-coated surfaces with only 1 failure).

The success rate (defined as bone resorption <1.5 mm after the first year of loading and <0.2 mm thereafter) was 97.2%. Immediate nonocclusal loading of single implants is a reliable surgical-prosthetic procedure with a low rate of implant loss and a low quantity of peri-implant bone loss over time.

© J Oral Implantol 2006;32:43-51

Background:
Rigid temporization has been recognized to have a significant impact on the peri-implant tissue response in immediate implant loading since it reduces the mechanical stress exerted on each implant.

Purpose:
A successful protocol for immediate loading of multiple implants depends on an adequate fixation and immobility of the implants to prevent the risk of micromovements in relation to the surrounding bone. The objective of this article was to evaluate a prosthetic concept for an accelerated rigid splinting of multiple implants for same-day immediate loading with metal-reinforced provisional restorations using a technique of welding temporary implant abutments with a prefabricated titanium bar directly in the oral cavity (syncrystallization).

Materials and Methods:
Between June 2004 and January 2005, immediate loading of threaded implants with a metal-reinforced acrylic resin provisional restoration at stage 1 surgery was evaluated in 40 consecutive patients. A total of 192 implants were placed in selected edentulous or partially edentulous patients using the syncrystallization technique.

Once the titanium bar was welded intraorally to the abutments, opaque was applied and the provisional restoration was relined and screw-retained the same day. In addition, a comparison of deformations and stress distributions in implant-supported, metal-reinforced and nonmetal-reinforced resin provisional restorations was analyzed in the edentulous mandible by a three-dimensional finite element model (FEM).

Results:
All of the 192 rigidly temporized immediately loaded implants osseointegrated. An implant success rate of 100% was achieved over a period of 6 months postplacement. No fracture or luting cement failure of the provisional restoration occurred during the observation time. Compared to mere acrylic superstructures, a significant reduction of deformation and strain within metal-reinforced provisional restorations was detected by FEM analysis.

Conclusion:
The results of this study indicate that the syncrystallization technique allows an expedite and adequate rigid splinting of multiple immediately loaded implants. The advantages of the technique are:

1. reduction of treatment time for immediate temporization at stage 1 surgery;
2. predictable fixation and immobility of implants in the early stages of bone healing; and
3. less time for repairing provisional restorations as a result of no or rare fracture.

© Clin Implant Dent Relat Res 2006;8:123-134

The maxillary posterior region of the mouth sustains greater bite forces compared to the anterior, yet often presents the poorest bone density. A biomechanical approach, often presented to decrease risk factors in regions of high stress or poor bone density, is to increase implant surface area. Most manufacturers provide implants in variable lengths.

Sinus grafts permit longer implants; however, finite element analysis support the hypothesis that implant length is a secondary parameter for stress distribution. A more beneficial approach, to enhance implant surface area in the posterior regions, has primarily been to increase the implant diameter. However, when conventional designs and diameters are used, this only increases surface area by 30% yet bite forces increase by more than 300% in the posterior regions.

A change in implant diameter and thread design (i.e. BioHorizons Implant System, Inc.) may increase surface area by more than 300%. This clinical report demonstrates an implant surgical success rate of 99.4% in the posterior maxilla, using the bone quality-based implant system from BioHorizons. In addition, there were no early loading failures and no prosthetic failures.

Crestal bone loss during early loading averaged .71 mm or less, dependent upon a one-stage or two-stage surgical approach. The increase in surface area of this design, coupled with the compressive load thread of this design, may indeed be responsible for the decrease in early loading implant failure and also contribute to a decrease in crestal bone stresses, which may reduce crestal bone loss.

© Oral Health 2000;8:7-15

ABSTRACT

Objectives:
The use of osseointegrated implants as an endoestal anchorage device to provide support for dental prostheses is a reliable and widely accepted treatment modality. The purpose of this study was to evaluate the clinical performance of biohorizons implants placed in the maxilla or in the mandible.

Methods:
One hundred fifty-five consecutive patients (71 men, 84 women), aged between 18 and 72 years (mean: 54 years) participated in this study. A total of 500 implants (internal; BioHorizons, Birmingham, AL, USA) were inserted. The cases were examined retrospectively in order to evaluate the clinical efficiency of BioHorizons implants and to determine the success rate of implant retained/supported prosthesis after a 5-year period. All implants were assessed clinically and radiographically on a yearly basis.

Results:
One hundred fifty-five consecutive patients (71 men, 84 women), aged between 18 and 72 years (mean: 54 years) participated in this study. A total of 500 implants (internal; BioHorizons, Birmingham, AL, USA) were inserted. The cases were examined retrospectively in order to evaluate the clinical efficiency of BioHorizons implants and to determine the success rate of implant retained/supported prosthesis after a 5-year period. All implants were assessed clinically and radiographically on a yearly basis.

Conclusion:
Within the limitations of the observation period and sample number, the present findings confirmed sufficient success and survival rates of BioHorizons implants placed in the mandible as well as implants placed in the maxilla after a 5-year period. We can then conclude these implants can be highly satisfactory from a clinical point of view.

© Ege University, Faculty of Dentistry, Izmir, Turkey

ABSTRACT
The aim of the present investigation was to evaluate the clinical and histologic results of a sinus augmentation procedure performed using calcium sulfate as the grafting material. A group of 12 patients (15 sinuses) formed the pilot group. Based on the experience of the pilot group, the technique of calcium sulfate application was modified, and a second group of 45 patients (50 sinuses) was subsequently treated (test group). In the pilot group, a total of 30 implants (Biolock) was placed. In the test group, a total of 100 implants (Biolock and BioHorizons) was placed. The clinical data reported in the present study are related to the 1-year follow-up for both groups. Clinical evaluations, including assessment of implant mobility and probing pocket depth, were recorded on a monthly basis following implant uncovering until final prosthesis placement, and every 6 months thereafter. Radiographs were taken prior to sinus augmentation, monthly until 6 months postoperatively, 9 and 12 months after implantation, and at yearly intervals thereafter. One implant in the pilot group was not integrated at second-stage surgery, and 1 in the test group failed to maintain osseointegration after the abutment connection (at the 1-year evaluation). Based on defined criteria, the overall success rate for the 130 placed implants 1 year postimplantation was 98.5%. Clinical and radiographic evaluation revealed that the augmentation procedure resulted in new tissue formation within the sinuses. The technique used in the test group suggested a slowdown in material resorption and a reduction in graft shrinkage during healing. Bone biopsies were harvested for histologic evaluation. The application of a resorbable barrier membrane to the access window reduced the invagination of soft tissue at that level. The results of this study support the hypothesis that calcium sulfate may be a suitable material for sinus augmentation.

© Int J Oral and Maxillofac Implants. 1999 Nov-Dec;14(6):869-878.

Background:
Implants <10 mm long in the posterior regions of partially edentulous patients have a higher failure rate in many clinical reports. The purpose of this case series study was to evaluate implant survival when a biomechanical approach was used to decrease stress to the bone-implant interface.

Methods:
A retrospective evaluation of 273 consecutive posterior partially edentulous patients treated with 745 implants, 7 or 9 mm long, supporting 338 restorations over a 1- to 5-year period was reviewed from four private offices. Implant survival data were collected relative to stage I to stage II healing, stage II to prosthesis delivery, and prosthesis delivery to as long as 6 years follow-up.

A biomechanical approach to decrease stress to the posterior implants included splinting implants together with no cantilever load, restoring the patient with a mutually protected or canine guidance occlusion, and selecting an implant designed to increase bone-implant contact surface area.

Results: Of the 745 implants inserted, there were six surgical failures from stage I to stage II healing. All five failures were with a one-stage surgical approach (240 implants). There were two failures from stage II healing to prosthesis delivery. No implants failed after the 338 final implant prostheses were delivered. A 98.9% survival rate was obtained from stage I surgery to prosthetic follow-up.

Conclusions:
Short-length implants may predictably be used to support fixed restorations in the posterior partial edentulism. Methods to decrease biomechanical stress to the bone-implant interface appear appropriate for this treatment.

© J Periodontol 2006; 77:1340-1347

ABSTRACT
Purpose:The aim of this clinical trial was to evaluate the influence of gingival tissue thickness on crestal bone loss around dental implants after a 1-year follow-up.

Materials and Methods: Forty-six implants (23 test and 23 control) were placed in 19 patients. The test implants were placed 2mm subcrestally, whereas the control implants were positioned at bone level. Before implant placement, the tissue thickness at implant sites was measured with a periodontal probe. After healing, metal-ceramic cement-retained prostheses were constructed. According to tissue thickness, the test implants were divided into A (thin) and B (thick) groups. Intraoral radiographs were performed and crestal bone changes were measured at implant placement and after 1 year.

Results: Mean bone loss around the test implants in group A (thin mucosa) was 1.61 ± 0.24mm (SE; range, 0.9 to 3.3mm) on the mesial and 1.28 ± 0.167mm (range, 0.8 to 2.1mm) on the distal. Mean bone loss in test group B (thick mucosa) implants was 0.26 ± 0.08 mm (range, 0.2 to 0.9 mm) on the mesial aspect and 0.09 ± 0.05 mm (range, 0.2 to 0.6 mm) on the distal aspect. Mean bone loss around control implants was 1.8 ± 0.164 mm (range, 0.6 to 4.0 mm) and 1.87 ±  0.166 mm (range, 0.0 to 4.1mm) on the mesial and distal aspects, respectively. Analysis of variance revealed a significant difference in terms of bone loss between test A (thin) and B (thick) groups on both the mesial and distal.

Conclusion: Initial gingival tissue thickness at the crest may be considered as a significant influence on marginal bone stability around implants. If the tissue thickness is 2.0mm or less, crestal bone loss up to 1.45mm may occur, despite a supracrestal position of the implant-abutment interface.

© Int J Oral Maxillofac Implants. 2009 Jul-Aug, 24(4): 712-9.

ABSTRACT
Purpose:The aim of this pilot study was to determine what effect thin mucosal tissues can have on crestal bone stability around implants with platform switching.

Materials and Methods: Twelve 2-piece implants, consisting of 6 implants with horizontally matching implant-abutment connection (control) and 6 implants with platform switching (test) were placed in four patients. The mean age of the patients was 43 years (range, 37 to 56 yrs). Mucosal tissue thickness at implant sites was measured to be 2mm or less. Implants were restored with 5 splinted crowns and single 3-unit fixed partial denture. Intraoral radiographs were obtained and crestal bone changes were measured at implant placement and after a 1-year follow up post-treatment. The statistical significance level was set to P less than .05.

Results: Bone loss around the test implants was 1.81 ± 0.39mm on the mesial side and 1.70 ± 0.35mm on the distal aspect. Control implants overcame marginal bone resorption equaling 1.60 ± 0.46mm on the mesial side and 1.76 ± 0.45mm on the distal measurement. No statistically significant difference was found between control and test implants either mesially (F[1,10} = 0.746; P = .408) or distally (F[1,10} = 0.080; P = .783).

Conclusion: Within the limitations of this pilot study it can be concluded that implants with platform switching did not preserve crestal bone better in comparison with implants with traditional implant-abutment connection if, at the time of implant placement, thin mucosal tissues were present.

© J Oral Maxillofac Surg. 2010 Sep; 68(9): 2272-7.

The presence of fibrous tissue has long been known to decrease the long-term survival of a root-form implant. Excessive loads on an osseointegrated implant may result in mobility of the supporting device, and excessive loads may also fracture an implant component or body. Although several conditions may cause crestal bone loss, one of these may be prosthetic overload.

Excessive loads on the bone cause strain conditions to increase. These microstrains on the bone may affect the bone-remodeling rate in a direct relationship.

When strain conditions to the interfacial bone are in the mild overload zone, an increased bone remodeling response occurs, which results in a reactive woven bone formation that is less mineralized and weaker. Greater stresses may cause the interfacial strain to reach the pathologic overload zone and may cause microfracture of the bone, fibrous tissue formation, and/or resorption.

Recent reports suggest that the bone remodeling rate next to an implant may be used to evaluate biomechanical conditions and their influences on the implant-to-bone interface. These include a number of factors, such as loading conditions, implant body surface conditions, and implant design. For a given load condition, the implant design is one of the primary factors that determine the resulting strain at the interface.

A predetermined goal was established to bioengineer a dental implant to load the bone at the interface in a predetermined stress/strain relationship, in order to maintain lamellar bone at the interface. A case report is presented of 2 bioengineered implants loaded for 1 year, which demonstrated that the bone was primarily lamellar in structure, the bone turnover rate was less than 5 microns/day, and was the same as the bone away from the interface.

These findings corroborate those observed in a prior animal study reported with the same implant design. Although the number of implants evaluated in those two reports is few, they support a predetermined, histological outcome.

© J Periodontol 2001;72:1276-1286